Progression of Pharmacy Over the Years

Blow-Fill-Seal is the Next Evolution of IV Delivery

1960’s

1980’s

2020’s

Blow-Fill-Seal (BFS) technology is the latest innovation for IV bags. BFS is an FDA-recognized advanced aseptic filling technology, used around the world to fill-finish 20+ billion units of sterile liquids each year.

The basic concept of BFS is that a container is formed, filled, and sealed in a continuous process without human intervention, in a sterile enclosed area inside a machine, reducing the risk of exposure to the outside environment.

It’s an ingenious invention and the most critical process in pharmaceutical production. BFS containers are manufactured and filled in a single step under clean-room sterile conditions. The strictest hygiene, quality, and GMP requirements must be and are met”

Darren Alkins, CEO

Advantages of the BFS Innovation:

Good overall eco-balance

Plastics tie up fewer resources than glass during production and disposal. In addition, less CO² is produced because the transport weight is lower and no empty containers are transported.

Recyclable pharma-grade monomer material

Production waste is re-granulated and reused in the BFS process or returned to the recyclable material cycle, for example, for film production.

Efficient, durable equipment

We offer the best quality and continuously optimize bottle pack models for less energy and material consumption as well as heat recovery.

Sustainable lifecycle service

Once infusion is completed the BFS container is disposed then by incineration, produces water and carbon dioxide.

Key Pharmacy Advantages:

The BFS container design characteristics help reduce the potential risks during the processes of drug admixture and delivery.

The ergonomic design of the bottle and its large neck ring help protect from sharps injuries and allow a comfortable and stable handling.
The port system has two identical ports which can be used for admixture and/or delivery interchangeably.
The germ-free port under the plastic seal design helps protect from potential microbial ingress into the IV solution.
The full collapsibility of the BFS container in a closed system helps to reduce microbial and chemical contamination.
The regular flow rate and accurate graduation scale facilitate patient monitoring and help reduce medication errors.
The large-sized text, color coding and geometrical elements of the label help reduce potential selection errors.
The material resistance of the BFS container helps to prevent damages during transport.
Thanks to its shape, the BFS container is easy to store and count.
The Polyethylene material is free of PVC, DEHP and Latex offers good compatibility with most drugs. No need to stock two types of bags.

Blow Fill Seal technology is superior for sterile products because it significantly reduces the risk of contamination by automating the entire process within a sterile environment. This minimizes human intervention and enhances product safety”

Steven D’Amico, RPh